Here’s a concise overview of Adipex‑P:
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What it is: Brand name for phentermine hydrochloride, a stimulant (sympathomimetic amine) used as a short‑term adjunct to diet and exercise for weight loss in adults with obesity or overweight with weight‑related conditions. In the U.S., it’s a Schedule IV controlled substance.
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How it works: Suppresses appetite and increases norepinephrine activity in the CNS, helping reduce caloric intake.
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Usual dosing: Commonly 37.5 mg once daily (tablet/capsule), taken in the morning before breakfast or 1–2 hours after to reduce insomnia. Your prescriber may adjust dose or frequency. Typically prescribed for a few weeks; longer use is off‑label and should be supervised.
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Common side effects:
- Dry mouth, constipation, insomnia
- Increased heart rate, elevated blood pressure, palpitations
- Nervousness, restlessness, anxiety, headache
- Nausea, changes in libido
- Risk of tolerance, dependence, and withdrawal if abruptly stopped
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Serious/urgent signs (seek medical care immediately):
- Chest pain, fainting, shortness of breath
- Severe headache, vision changes, very high blood pressure
- Signs of pulmonary hypertension or valvular heart disease (rare; risk higher with combination “diet pill” use)
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Do not use if you have:
- Uncontrolled hypertension, significant cardiovascular disease, arrhythmias, stroke history
- Hyperthyroidism, glaucoma, agitated states
- History of drug misuse/dependence
- Use of MAO inhibitors within 14 days (e.g., phenelzine, tranylcypromine, linezolid)
- Pregnancy or breastfeeding
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Use with caution/monitoring:
- Controlled hypertension, diabetes (may lower insulin/oral hypoglycemic needs), renal impairment
- Avoid other stimulants (e.g., amphetamines, high caffeine), decongestants, and alcohol
- Potential interactions with serotonergic agents; discuss all meds and supplements with your clinician
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Practical tips:
- Take early in the day to avoid insomnia
- Combine with a reduced‑calorie, high‑protein/vegetable‑rich diet and regular physical activity
- Track blood pressure, heart rate, sleep, mood, and weight weekly
- If you miss a dose, skip if it’s late in the day; don’t double up
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Alternatives your clinician might consider:
- GLP‑1 receptor agonists (e.g., semaglutide, tirzepatide)
- Orlistat, naltrexone/bupropion, phentermine/topiramate ER
- Intensive lifestyle programs, CBT for eating behaviors, bariatric surgery evaluations (when indicated)






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